Clarithromycin use in pregnancy and lactation

Clarithromycin's pregnancy category according to the FDA (Food and Drug Administration) and the Australian Therapeutic Goods Administration (TGA) is as follows:

Pregnancy     Category C       ( by FDA )

                       Category  B3       (AU TGA )

1. Pregnancy: Clarithromycin is typically classified as pregnancy category C by the FDA. This means that animal reproduction studies have shown adverse effects on the fetus, but there are no adequate and well-controlled studies in humans. The medication may be used during pregnancy if the potential benefits justify the potential risks to the fetus. However, caution is advised, and alternative antibiotics may be considered when possible.

1. Lactation: Clarithromycin is excreted into breast milk, and it is generally recommended to avoid its use during breastfeeding unless the benefits outweigh the potential risks to the infant. If clarithromycin is necessary for the mother's health, healthcare providers may recommend closely monitoring the infant for any potential adverse effects.