Metoprolol use during pregnancy and lactation

Metoprolol, like other beta-blockers, is generally not recommended for routine use during pregnancy, especially during the first trimester. While data on the safety of metoprolol in pregnant women is limited, there are concerns about potential risks to the fetus.

1. Fetal Growth Restriction: Some studies have suggested a potential association between beta-blocker use during pregnancy, including metoprolol, and fetal growth restriction. This means the fetus may not grow at the expected rate, leading to low birth weight or other complications.

2. Cardiovascular Effects: Beta-blockers, including metoprolol, can cross the placenta and affect the cardiovascular system of the developing fetus. This can potentially lead to bradycardia (slow heart rate), hypotension (low blood pressure), or other cardiovascular issues in the fetus.

3. Neonatal Effects: There have been reports of neonatal complications, such as hypoglycemia (low blood sugar), respiratory depression, and bradycardia, in infants born to mothers who took beta-blockers, including metoprolol, during pregnancy.

Pregnancy     Category D       ( by FDA )

                       Category  D       (AU TGA )